来自肠道的 Lactobacillus rhamnosus GG 通过微生物群重塑和托芬代谢重编程缓解产母的肠道炎症
Mingyan Zhao1, Felix Kwame Amevor2, Liqiang Liu1
1College of Animal Science and Technology, Southwest University, No. 2 Tiansheng Road, Beibei 400715, Chongqing, PR China.
Journal of agricultural and food chemistry
|January 6, 2026
概括
来自的本土乳酸菌种拉姆诺索斯GG (LGG) 菌株可以对抗肠道炎症. LGG通过调节肠道微生物群和新陈代谢来改善肠道健康,生长和屏障完整性,提供无抗生素的家禽解决方案.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道炎症对家禽的健康,营养吸收和生产力产生负面影响.
- 硫酸德克斯 (DSS) 是动物模型中实验性肠道炎症的常见诱导剂.
研究的目的:
- 从土著中分离和鉴定一种本地肠道寄生菌株Lactobacillus rhamnosus GG (LGG) 的特征.
- 评估口服LGG对产卵母的DSS诱导的肠炎的预防作用.
主要方法:
- 在DSS挑战之前,口服给产母隔离的LG菌株.
- 评估生长性能,抗氧化能力和肠道形态.
- 通过紧密结节基因表达对上皮质屏障完整性的分析.
- 测量促炎和抗炎细胞因子水平 (IL-1β,IFN-γ,TGF-β).
- 16S rRNA基因测序用于肠道微生物社区概况.
- 非向的代谢学来识别代谢变化,特别是在托代谢中.
主要成果:
- 使用LGG显著改善了DSS诱导炎症的母的生长性能和抗氧化能力.
- 通过上调紧密结基因,恢复肠结构和增强上皮质屏障完整性.
- 显著减少促炎性细胞因子 (IL-1β,IFN-γ) 和增加TGF-β.
- 肠道微生物多样性的正常化,Firmicutes/Bacteroidetes比率的修正,有益细菌 (Lactobacillus,Lachnoclostridium) 的丰富,以及致病性属 (Escherichia,Bacteroides) 的减少.
- 显著调节托新陈代谢,含有高水平的氨酸,氨酸和氨酸.
结论:
- 原生乳杆菌 (Lactobacillus rhamnosus GG) 有效地减轻产卵母的DSS诱导的肠炎症.
- 通过重塑肠道微生物群和重新编程宿主新陈代谢,特别是托通路,LGG具有保护作用.
- 这些发现支持本地LGG作为一种无抗生素策略的潜力,以提高家禽的肠道健康和生产力.
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