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黄可以通过调节YAP/TEAD信号通路来缓解胃癌前病变

Jinhao Zeng^1,2, Shangbin Lv³, Maoyuan Zhao⁴

¹TCM Prevention and Treatment of Metabolic and Chronic Diseases Key Laboratory of Sichuan Province, Chengdu, China.

Phytotherapy research : PTR

|January 6, 2026

概括

黄素 (CUR) 可以通过减少炎症和调节YAP/TEAD通路来预防和治疗胃癌前病变 (GPL). 这种天然化合物有望缓解胃粘膜损伤.

科学领域:

胃肠病学胃肠病学
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

胃癌前病变 (GPL) 构成严重的健康风险,有效的治疗方法有限.
黄素 (CUR) 源自Curcuma longa Linn.,以其生物活性而闻名,但其在GPL中的作用尚未被探索.
了解GPL中CUR的机制对于开发新型治疗策略至关重要.

研究的目的:

研究黄素 (CUR) 对胃癌前病变 (GPL) 的治疗作用.
在 GPL 的 in vitro 和 in vivo 模型中阐明 CUR 作用的潜在分子机制.
评估CUR对胃炎和细胞增殖的影响.

主要方法:

使用了一种由N-甲基-N'-尼特罗-N-尼特罗斯瓜尼丁 (MNNG) 诱导的GPL鼠标模型.
在体外研究中使用了人类胃上皮细胞 (MC细胞) 恶性转化模型.
进行了生物化学测定,免疫组织化学和细胞因子水平分析.

主要成果:

在GPL大鼠中,CUR治疗逆转了肠道转化和失生症.
胃素17,素I (PG I),前列腺素E2 (PGE2),以及各种间白蛋白 (ILs) 和瘤坏死因子α (TNF-α) 的CUR调节水平.
CUR降低了YAP1和TEAD1的表达,同时提高了p-YAP1和与亡相关的蛋白质的调节,这表明Hippo信号通路的调节.

结论:

黄素 (CUR) 有效地缓解胃粘膜炎症,并防止胃癌前病变 (GPL) 的发生和进展.
CUR的治疗潜力可以通过在Hippo信号通路内的YAP/TEAD轴的调节来调节.
这些发现强调了CUR作为预防和治疗GLP的有前途的药物.

关键词:

TEA 域转录因子 1 的转录因子.灭症 (apoptosis) 是一种死亡的过程.库尔库明是一种黄素.胃癌前期病变的胃病变.它们的扩散和扩散.是的相关蛋白 1 1

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