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Updated: Jan 13, 2026

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乌比奎丁E3酶HRD1通过抑制PPARα驱动的m6ARNA修饰来限制肝脏脂质代谢

Hyunbae Kim1, Pattaraporn Thepsuwan1, Juncheng Wei2

  • 1Center for Molecular Medicine & Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Science signaling
|January 6, 2026
PubMed
概括

E3无素酶HRD1通过减少N-甲基氨酸 (m6A) RNA修饰和关键脂质代谢基因的表达,促进肝脏脂质的积累. HRD1降解PPARα,影响m6A调节器和肝脂质平衡.

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