21世纪的帕拉科西迪奥伊多米科斯:挑战和里程碑
James Venturini1, Norma Beatriz Fernandez2,3, Priscila Marques de Macedo4
1School of Medicine, Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
PLoS neglected tropical diseases
|January 6, 2026
概括
抛弃的真菌疾病 - - 偏菌菌症 (PCM) - - 由于缺乏认识和监测,其诊断不足. 了解PCM的进展受到诊断和治疗挑战的阻碍,影响患者的生活质量.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 甲状腺菌 (PCM) 是一种被忽视的热带真菌感染,在拉丁美洲普遍存在,不成比例地影响弱势群体.
- 尽管PCM对健康有重大影响,但由于意识和监测有限,PCM往往被诊断不足,报告不足.
- 本综述综合了PCM病因学,流行病学,诊断,治疗和社会影响的最新知识.
研究的目的:
- 提供对近期的帕拉科西迪奥伊多米科斯 (PCM) 进展的全面概述.
- 突出当前的挑战,并确定PCM研究和管理的知识差距.
- 为PCM未来的研究方向和公共卫生战略提供信息.
主要方法:
- 在2001年至2025年期间从PubMed和虚拟健康图书馆 (BVS) 系统地检索文献.
- 用关键词"Paracoccidioidomycosis"和"Paracoccidioides"进行文章搜索.
- 两位专家根据主题领域对文章进行了免复制和独立审查.
主要成果:
- 由于生态和社会经济变化,PCM流行病学正在演变,影响疾病模式.
- 由于有限的方法和缺乏标准化测试,诊断方面的挑战仍然存在.
- 目前的治疗方法有局限性,PCM显著影响患者的生活质量,包括社会和心理方面.
结论:
- 需要采用综合方法,包括改善监测,诊断和治疗方法.
- 有针对性的社会支持计划对于管理PCM更广泛的后果至关重要.
- 国际合作和持续的研究对于解决知识差距和改善患者结果至关重要.
相关概念视频
Fungal Phylum Microsporidia
413
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
413
Pulmonary Tuberculosis II
1.4K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.4K
Pulmonary Tuberculosis III
921
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
921
Cystic Fibrosis: Management
465
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
465
Pulmonary Tuberculosis I
820
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
820
Skin Diseases and Disorders
5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K


