哈西莫托甲状腺炎和乳头甲状腺癌的进展:10年回顾性队列研究
Xin Li1, Xiangyun Yao2, Rui Shan3
1Department of General Surgery, Peking University Third Hospital, Beijing, China.
JMIR cancer
|January 6, 2026
概括
哈西莫托甲状腺炎 (HT) 在积极监测 (AS) 期间似乎没有影响乳头甲状腺癌 (PTC) 的进展. 然而,患有HT的超重或肥胖患者显示PTC进展的风险增加.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 全球甲状腺癌的发病率正在上升.
- 乳头甲状腺癌 (PTC) 是最常见的类型.
- 主动监控 (AS) 是一种越来越多地用于低风险PTC的管理策略.
研究的目的:
- 调查哈西莫托甲状腺炎 (HT) 与乳头甲状腺癌 (PTC) 进展之间的关联,在接受主动监测 (AS) 管理的患者中.
- 探索临床因素对HT-PTC进展关系的潜在影响修改.
主要方法:
- 对203名PTC患者进行了回顾性研究,他们接受了至少6个月的AS.
- 患者分为HT (n=90) 和非HT (n=113) 组.
- 考克斯的比例危险模型和子组分析用于评估进展风险,调整共变量.
主要成果:
- 在HT和非HT组之间,无进展生存,无瘤扩大生存或无淋巴结转移生存没有显著差异.
- 亚组分析显示,在超重/肥胖患者 (BMI>24 kg/m2) 中,HT与增加PTC进展风险之间存在显著的关联.
- 在BMI ≤24 kg/m2的患者中,没有观察到HT与进展风险之间的关联.
结论:
- 哈西莫托甲状腺炎 (HT) 在一般队列中没有与乳头甲状腺癌 (PTC) 在主动监测 (AS) 下的进展相关.
- 超重或肥胖状态可能会改变HT和PTC进展之间的关系,这表明这个子组的风险更高.
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