脑电图是否有助于预测神经毒性和与化学抗原受体 (CAR) T 细胞治疗相关的结果?

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Updated: Jul 8, 2026

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Published on: November 12, 2019

Brin E Freund¹, Adrian Safa¹, Filippo Emanuele Colella²

¹Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

|January 6, 2026

概括

高龄和治疗前脑电图 (EEG) 的普遍减缓可能预测接受CAR T细胞治疗的患者的免疫效应细胞相关神经毒性综合征 (ICANS). ICANS与更长的住院时间和较差的生存率有关.

科学领域:

神经科学是一个神经科学.
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

化学抗原受体 (CAR) T细胞疗法为癌症治疗提供了一种革命性的方法.
免疫效应细胞相关神经毒性综合征 (ICANS) 是CAR T细胞治疗的重要潜在副作用.
电脑电图 (EEG) 已经成为预测和监测ICANS的潜在工具.

研究的目的:

评估治疗前的EEG,神经成像和临床因素来预测ICANS.
在经历ICANS的患者中评估EEG的预后价值.

主要方法:

一项回顾性多中心研究包括207名接受CAR T细胞治疗的成年患者.
用单变量,多变量和生存分析分析数据.
在包括的50.2%的患者中,治疗前的EEG可用.

主要成果:

高龄和治疗前EEG总体减速与ICANS风险增加有关.
没有发现任何治疗前的因素可以预测ICANS患者的住院时间或存活率.
患有ICANS的患者住院时间较长,12个月和24个月生存率明显较低.

结论:

ICANS与长时间住院和降低生存结果有关.
年龄的增长是发展ICANS的一个危险因素.
治疗前的EEG,特别是通用减速,可能有助于识别患有ICANS风险较高的患者.

关键词:

用CAR T细胞疗法进行治疗.癌症癌症癌症癌症这是一个EEGEEGEEGEEGEEGEEGEEG.免疫效应细胞相关的神经毒性综合征神经毒性神经毒性发作发作发作

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