相关实验视频
Updated: Jan 13, 2026
03:20
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
Published on: August 19, 2025
1.8K
紫外线辐射重塑了人类皮肤衰老的转录组景观:来自多年龄比较研究的见解
Jiaqi Zhang1, Xueli Jia2, Qitian Fu1
1Department of Cosmetics, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 102488, China.
Journal of photochemistry and photobiology. B, Biology
|January 6, 2026
概括
紫外线 (UV) 辐射从根本上重新连接皮肤衰老,与内在衰老不同. 关键的驱动因素包括Sirtuin枯竭和慢性炎症,为抗光衰老治疗提供了新的点.
科学领域:
- 皮肤病学和分子生物学
- 基因组学和生物信息学
- 衰老研究研究 衰老研究
背景情况:
- 皮肤衰老的结果来自内在因素和外在影响,如紫外线 (UV) 辐射,导致光衰老.
- 在人类一生中,区分内在衰老与紫外线诱导的光衰老的分子机制尚未完全理解.
研究的目的:
- 在年轻人,中年人和老年人群中,比较照片老化 (子) 和内在老化 (胸部) 皮肤的转录形状.
- 将转录组数据与生物物理皮肤测量进行整合.
主要方法:
- 从30名女性志愿者在三个年龄组的皮肤活检的转录组分析.
- 不同基因表达,基因本体学 (GO) 和KEGG通路丰富分析.
- 分子发现与生物物理参数 (屏障功能,弹性,色素,微观结构) 的相关性.
主要成果:
- 照片老化皮肤显示了加速的转录基因失调,涉及DNA损伤,压力信号,代谢重编程和瘤性途径.
- 在光衰老的皮肤中观察到持续的伪炎状态和Sirtuin表达的减弱 (SIRT1,SIRT5).
- 内在衰老涉及到稳态的逐渐下降,而紫外线暴露独特地破坏了间隙结和细胞骨组织.
结论:
- 紫外线辐射从根本上改变了皮肤衰老网络,与内在衰老相比,创造了不同的分子通路.
- 锡尔图因枯竭,异常的压力信号和慢性伪炎是光衰老的关键驱动因素.
- 已识别的分子驱动因素为抗光衰老干预提供了新的治疗点.
更多相关视频
相关概念视频
01:35Mutations
42.7K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
42.7K
01:39Mutations
94.3K
Overview
94.3K
01:38Nucleotide Excision Repair
5.0K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.0K
01:08Nucleotide Excision Repair
40.6K
Overview
40.6K
01:19Pigmentation
4.1K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.1K
01:12Renewal of Skin Epidermal Stem Cells
3.0K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.0K