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Updated: Jan 13, 2026

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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Published on: March 28, 2017

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代谢物在药物相互作用中的作用

Nina Isoherranen1

  • 1Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA, United States.

Drug metabolism and pharmacokinetics
|January 6, 2026
PubMed
概括

预测循环药物代谢物对于安全性测试至关重要. 本综述涵盖了当前的建议,评估了代谢物抑制和药物代谢酶和载体的诱导,并讨论了PBPK建模以更好地评估风险.

关键词:
细胞染色体P450的使用.药物相互作用 药物相互作用酶抑制可以抑制酶.在体外到体内生物预测.代谢产物的代谢物在 PBPK 建模中使用 PBPK 模型.

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