在子宫内暴露于药物和先天性眼睛异常
Réjane Mairesse1, Marianne Lepetit1, Charlotte Dubucs2
1Medical and Clinical Pharmacology Department, CHU Toulouse, Toulouse University, Toulouse, Occitanie, France.
BMJ open ophthalmology
|January 6, 2026
概括
这项研究分析了与怀孕期间使用的药物相关的先天性眼睛疾病的国际药监数据. 它确定了常见的异常和可疑药物,包括已知的原体和其他记录较少的风险.
科学领域:
- 药物监督 药物监督 药物监督
- 眼科医生 眼科 眼科
- 甲状腺学 甲状腺学
背景情况:
- 先天性眼睛异常是一个重大问题,了解怀孕期间的药物风险至关重要.
- 国际药监数据库提供了对药物不良事件的洞察,包括影响胎儿发育的药物不良事件.
研究的目的:
- 在国际药物监督数据库中描述先天性眼睛异常的报告.
- 为了确定在子宫内暴露后与先天性眼睛异常相关的药物.
主要方法:
- 一项描述性,回顾性研究,分析了有关"先天性眼睛疾病"的报告.
- 包括有记录的跨胎盘药物管理的病例.
- 使用R软件进行的统计分析.
主要成果:
- 最初提取了2923份关于子宫内药物暴露和眼睛异常的报告,其中676份被选择.
- 最常见的异常包括眼皮 (17.3%),眼器 (9.4%) 和轨道 (1.1%) 的缺陷.
- 疑似药物包括已知原体 (酸,酸) 和其他如氧化和丹塞.
结论:
- 这项研究提供了关于药物暴露和先天性眼睛异常的新数据,这些异常可能会使人衰弱.
- 我们承认药监数据库在确定因果关系方面的局限性.
- 结果作为未来研究的基础,使用不同的方法和数据源.
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