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在小鼠,几内亚猪和老鼠中的布洛芬等离子体的立体选择性药理学

Huanhuan Yang1, Yuexin Li1,2, Changqing Xu3

  • 1Guollence Pharmaceutical Technology Co. Ltd., Beijing, China.

Chirality
|January 6, 2026
PubMed
概括

布洛芬 (IBU) 在老鼠,小鼠和几内亚猪中经历单向转化,从R-IBU转化为S-IBU,其中S-enantiomer暴露率更高. 这项立体选择性药理动力学研究揭示了生物转化速率的显著物种间差异.

关键词:
(R) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 布洛芬是最常见的药物之一,也是最常见的一种.(S) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -在 LC-MS/MS 中使用.吉拉式转换率是指吉拉式转换率.它们是反体的反体.几内亚猪 几内亚猪鼠标 鼠标 鼠标 鼠标鼠类 鼠类 鼠类 鼠类 鼠类种类的差异 种类的差异 种类的差异立体选择性药理动力学

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