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相关概念视频

Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

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Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
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一个纳米功能释放囊的一般多层模型:一个实验驱动的计算研究.

Elia Onofri1, Emiliano Cristiani1, Andrea Martelli2

  • 1Istituto per le Applicazioni del Calcolo (IAC), National Research Council of Italy (CNR), Rome, Italy.

Mathematical biosciences and engineering : MBE
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概括

本研究提出了从多层微囊中释放药物的计算模型,考虑到囊侵蚀和复杂扩散. 该模型准确地预测释放动力学,有助于设计先进的药物输送系统.

关键词:
生物组合物的生物组合物扩散方程 扩散方程药物释放释放药物释放药物释放的时间微囊中的微囊.数字解决方案的数值解决方案

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科学领域:

  • 生物医学工程 生物医学工程
  • 材料科学 材料科学 材料科学
  • 计算建模 计算建模

背景情况:

  • 释放囊对于药物输送至关重要,通常具有核心和同心涂层.
  • 现有的模型往往简化了囊结构和释放动态.

研究的目的:

  • 扩展多层囊的机械模型,包括并发侵蚀.
  • 为了计算性地描述活性物质释放动力学.
  • 为控制释放药物输送系统提供设计标准.

主要方法:

  • 开发了一个从球形微囊中释放药物的计算模型.
  • 采用非线性扩散方程,具有不对称的扩散和不连续系数.
  • 使用具有自适应分辨率的有限体积方案以数值方式解决.
  • 对度和累积释放的衍生分析表达式.

主要成果:

  • 模型准确地预测了多层囊的释放概况.
  • 确定了影响释放动态的关键参数,例如涂层透性.
  • 模型预测与体外实验数据有很好的一致性.

结论:

  • 开发的模型提供了对复合粒子中运输过程的机械洞察力.
  • 作为评估和设计下一代药物输送系统的实用工具.
  • 减少了开发可控释放系统的实验力度.