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相关概念视频

Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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相关实验视频

Updated: May 13, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses
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量化眼睛表面的变化与隐形眼镜的磨损.

Lucia Carichino1, Kara L Maki1, David S Ross1,2

  • 1School of Mathematics and Statistics, Rochester Institute of Technology, 85 Lomb Memorial Drive, Rochester, NY 14623, USA.

Mathematical biosciences and engineering : MBE
|January 6, 2026
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种新的数学模型来模拟隐形眼镜和眼睛的相互作用,揭示了隐形眼镜的特性如何影响眼睛的应力和变形. 这些发现提供了关于隐形眼镜不适和眼睛表面健康的见解.

关键词:
隐形眼镜的舒适性 隐形眼镜的舒适性有限元素模拟的模拟.非线性合器非线性合器眼睛的生物力学吸气压力 吸气压力

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相关实验视频

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科学领域:

  • 生物机械工程 生物机械工程
  • 眼科医生 眼科 眼科
  • 计算建模 计算建模

背景情况:

  • 数以百万计的人使用隐形眼镜,许多人因为不适而停止使用.
  • 隐形眼镜与眼睛表面之间的机械相互作用不太清楚,很难在临床上量化.
  • 对这些相互作用的现有研究是有限的.

研究的目的:

  • 开发第一个模拟隐形眼镜-眼睛表面机械相互作用的数学模型.
  • 为了预测新出现的属性,如镜头配置,吸气压力和眼睛变形.
  • 分析各种参数对这些相互作用的影响.

主要方法:

  • 开发了一种非线性数学模型,将隐形眼镜机制与眼睛表面生物力学结合起来.
  • 通过镜头后面的撕裂膜施加模拟的吸气压力.
  • 包含同质/异质线性弹性眼睛模型,多种眼镜和透镜形状/厚度.

主要成果:

  • 预测较高的眼睛变形和压力在中央和四肢/关节区域.
  • 证明异质的眼睛材料特性会放大眼睛的应力和变形.
  • 显示眼部位移和压力的非线性增加,随着隐形眼镜刚度的增加.
  • 发现更的镜头减少了眼睛中部的移位,但增加了外围的移位.

结论:

  • 该模型为了解隐形眼镜生物力学和眼睛表面反应提供了定量框架.
  • 研究结果强调了隐形眼镜设计和材料特性对眼睛健康的重大影响.
  • 该模型的预测与现有的实验数据和理论模型保持一致.