在暴露于烟草的个人中,肺功能轨迹的差异
Benjamin Grobman1, Amy L Non2, Elizabeth Baker3
1Harvard Medical School, Boston, Massachusetts, USA bgrobman@hms.harvard.edu.
Thorax
|January 6, 2026
概括
社会决定因素和环境暴露显著影响肺功能轨迹,特别是非西班牙裔黑人成年人. 了解这些因素对于制定有针对性的肺健康预防策略至关重要.
科学领域:
- 肺部医学 肺部医学
- 公共卫生 公共卫生
- 健康差异 在健康上的差异
背景情况:
- 肺功能轨迹受到健康的社会决定因素 (SDOH),环境暴露和病史的影响,但这些关系仍未得到充分探索.
- 了解这些因素对于制定肺部健康的有效预防策略至关重要.
研究的目的:
- 调查SDOH,环境暴露和病史与美国队列中的肺功能轨迹的关联.
- 在不同的人口群体中识别肺功能轨迹的差异.
主要方法:
- 来自COPDGene研究的纵向数据分析,包括2990名男性和2945名女性,年龄在45-80岁,有烟草暴露史.
- 贝叶斯轨迹建模用于分析支气管扩张后的1秒内强制呼气体积 (FEV1) 和强制生命能力 (FVC).
- 多项逻辑回归评估了SDOH,环境暴露和病史与已识别的肺功能轨迹的关联.
主要成果:
- 在每个性别中,分别发现了六种不同的肺功能轨迹.
- 与非西班牙裔白人成年人相比,非西班牙裔黑人成年人在较低的肺功能轨迹中更为普遍.
- 与下肺功能相关的因素包括非西班牙裔黑人种族,居住在美国东南部,终身喘和 COPD 父亲病史. 更高的收入和私人保险与下肺功能相反地相关.
结论:
- 非西班牙裔黑人和非西班牙裔白人成年人之间存在肺功能轨迹的显著差异.
- 个人和社区层面的因素,包括SDOH和环境暴露,与暴露在烟草中的个体的肺功能下降有关.
- 研究结果强调需要针对性干预,解决社会经济和环境因素,以改善肺部健康结果.
关键词:
肺部疾病,慢性阻塞性疾病相关概念视频
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