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脂质管理中的性别差异,LDL-C目标的实现,以及处方实践

Natasha Vartak¹, Caroline Ong¹, Xueqi Huang²

¹Northwell Health, Cardiovascular Institute, New Hyde Park, NY, USA (Drs Vartak, Ong, Weintraub, Parikh, Rosen, and Gianos).

Journal of clinical lipidology

|January 6, 2026

概括

妇女在脂质管理方面面临着显著的差异,接受的治疗不那么积极,并实现较低的LDL-C目标比男性. 提供者性别没有影响这些脂质治疗差距,突出了针对女性的有针对性的干预措施的需要.

科学领域:

心脏病学心脏病学
健康差异在健康上的差异
药物治疗药物治疗

背景情况:

降低脂质对于降低动脉样硬化心血管疾病 (ASCVD) 发病率和死亡率至关重要.
尽管有指导方针推的治疗方法,但在脂质管理方面仍然存在性别差异.
女性不太可能接受积极的治疗并达到最佳的低密度脂蛋白胆固醇 (LDL-C) 水平.

研究的目的:

调查提供者性别是否影响脂质治疗差距.
分析脂质管理和LDL-C目标实现中的基于性别的差异.

主要方法:

从2022-2023年对364,021名成年人的回顾性图表审查.
从电子健康记录中抽象人口,临床和处方数据.
基于ASCVD风险的最佳LDL-C的定义.

主要成果:

与男性相比,女性的平均LDL-C (108比102毫克/分升) 和LDL-C<100毫克/分升 (41%比47%) 的水平较高,较低.
在ASCVD患者中,女性的LDL-C<70 mg/dL显著降低 (31%对47%).
与男性相比,女性处方他类药物 (26%对33%) 和高强度他类药物 (23%对31%) 的可能性较低;提供者的性别没有影响.

结论:

患有ASCVD或处于ASCVD风险的女性的血脂降低疗法处方率和LDL-C目标实现率较低.
在脂质管理中存在的性别差异需要有针对性的干预措施.
提供者性别并不能解释妇女在脂质治疗中观察到的差异.

关键词:

心血管疾病是什么心血管疾病性别差异的性别差异脂质脂质脂质是一种预防预防预防提供者性别提供者性别类他类药物是一种药物.女性的健康妇女的健康

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