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抗菌活性斯塔菲洛科克斯表皮菌 CS05和伪菌光体 CS83从人类结膜囊中分离出来,对抗致病性细菌参考菌株的抗菌活性

Joicye Hernández-Zulueta¹, Alejandro González-De la Rosa^2,3

¹Laboratorio de Microbiología, Instituto de Fisiología Celular, Departamento de Biología Celular y Molecular, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Zapopan, Jalisco, México.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

|January 6, 2026

概括

来自人眼的共生细菌Staphylococcus epidermidis和Pseudomonas fluorescens,显示出作为对常见病原体的替代抗菌剂的潜力. 这项研究强调了眼睛表面微生物群作为新抗菌疗法的来源.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
生物技术是生物技术.

背景情况:

眼睛表面含有有益的细菌,对眼睛健康和免疫功能至关重要.
抗生素耐药性的增加需要探索新型抗菌源.
人的结膜囊是具有治疗功能的细菌的潜在储存库.

研究的目的:

从分类学上识别人类结膜囊中的细菌分离物CS05和CS83.
评估这些分离物对病原性细菌菌株的抗菌潜力.
探索使用眼部共生细菌作为替代抗菌剂来源的可行性.

主要方法:

从人类结膜囊中获得了CS05和CS83的细菌分离物.
使用桑格测序进行了分类学识别.
使用多种测定方法评估抗菌活性,包括交叉扩散,滴扩散,井扩散,磁盘扩散和微板测定与参考致病菌株相比.

主要成果:

分离物CS05被确定为葡萄球菌表皮菌,并抑制了大肠杆菌,李斯特菌单细胞菌,大麦芽菌,菌和金黄色葡萄球菌的生长.
分离CS83被确定为Pseudomonas fluorescens,并抑制了大肠杆菌,L. monocytogenes,Klebsiella pneumoniae,E. faecalis和S. aureus的生长.
两种已识别的细菌都表现出对一系列格拉姆阳性和格拉姆阴性病原体具有显著的抑制作用.

结论:

人的结节囊藏着具有强大的抗菌性质的细菌.
从眼睛表面获得的Staphylococcus epidermidis和Pseudomonas fluorescens是开发新型抗菌剂的有希望的候选人.
这些发现支持对眼睛微生物群的探索,作为打击抗生素耐药性的宝贵资源.

关键词:

伪omonas sp. 这种病毒是假的.斯塔菲洛可克菌 sp. 的存在.它具有抗菌活性,具有抗菌活性.开始的微生物群.结节囊是指结节囊中的一个.人类病原体的人类病原体

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