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Updated: May 6, 2026

Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta

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Published on: April 3, 2017

在子模型中,通过不同的给药途径对带介质 stromal 细胞进行比较生物分布分析

Liang Xiao¹, Chunlin Liu², Yuqian Wang³

¹1Department of Surgery and Oncology Shenzhen Second People's Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, China.

Acta pharmaceutica (Zagreb, Croatia)

|January 6, 2026

概括

通过对带介质干细胞 (UC-MSCs) 在脏治疗中的施用途径进行比较,干预注射显示出优异的分布和效率. 局部注射引起炎症,突出显示路线选择.

科学领域:

再生医学是一种再生医学.
干细胞生物学干细胞生物学
腎臟病學 (nephrology) 是一種醫學.

背景情况:

带介质干细胞 (UC-MSCs) 是对治疗脏疾病的有希望的.
有效地将UC-MSCs输送到脏对于治疗成功至关重要.

研究的目的:

为了比较UC-MSCs在静脉注射,局部脏注射或干预注射后脏组织中的分布和效率.
评估给药途径对脏向和潜在炎症反应的影响.

主要方法:

用DI标记的UC-MSCs通过三个途径给子:静脉注射,局部脏注射和干预注射.
在脏,肺部和大脑中UC-MSC的分布使用共聚焦显微镜进行了跟踪.
测量了炎症性细胞因子水平 (IL-6,TNF-α,IL-10).

主要成果:

干预注射实现了最高的输送效率 (12.4%),分布更加均.
局部脏注射导致局部度高,但对侧脏分布差.
静脉注射显示了有限的主导 (<1%),没有显著的间差异.
局部注射组表现出明显升高的炎症性细胞因子水平.

结论:

给药途径对UC-MSC分布和治疗中的向效率产生重大影响.
干预注射似乎是最有效的策略,精确的UC-MSC输送到脏.
要优化UC-MSC的治疗潜力并最大限度地减少不良影响,必须仔细考虑服用途径.

关键词:

交付方式交付方式干预程序是干预程序.干预性治疗是一种干预性治疗.介质细胞干细胞介质细胞干细胞脏器官是脏器官的一个组成部分.

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相关概念视频

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...