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经过压力训练的微藻机器人带有益生菌背包和肠车,用于炎症性肠病管理

Ruifeng Luo¹, Jinwei Liu¹, Linxin Dai²

¹State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, PR China.

Nature communications

|January 6, 2026

概括

一个新的生物混合机器人,EcN@PDA@HP,有效地向肠道提供抗氧化剂和益生菌. 这项创新通过恢复微生物平衡和减少氧化应激来缓解炎症性肠病 (IBD).

科学领域:

生物医学工程生物医学工程
微生物学微生物学
胃肠病学胃肠病学

背景情况:

炎症性肠病 (IBD) 的特点是肠道反应性氧物种 (ROS) 和失活性增加.
目前的治疗输送系统难以保护活性剂免受胃环境的影响,并且精确地准炎症的肠道区域.

研究的目的:

开发一种新的生物混合机器人,用于增强IBD治疗剂的递送.
克服当前交付系统在保护活性剂和实现有针对性的交付方面的局限性.

主要方法:

设计了一个生物混合机器人 (EcN@PDA@HP) 使用受压力训练的微藻 (Haematococcus pluvialis,HP) 和涂有多多巴胺 (PDA) 的大肠杆菌Nissle 1917 (EcN).
惠普被修改为胃弹性和增强的阿斯丁 (AST) 产量.
PDA涂层促进了EcN对炎症部位的粘附,并保持了其活性.

主要成果:

机器人EcN@PDA@HP证明了胃的快速通道和精确的保留在炎症的肠道区域.
生物混合机器人有效地清除了ROS,并在小鼠IBD模型中恢复了微生物群平衡.
联合抗氧化疗法 (AST) 和细菌疗法在缓解IBD症状方面被证明是有效的.

结论:

生物混合机器人EcN@PDA@HP是IBD治疗的一个有希望的策略.
这种方法可以改善抗氧化剂和益生菌的输送,解决IBD治疗的关键挑战.
这项研究强调了生物混合机器人的潜力,用于管理复杂的胃肠道疾病.

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