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Updated: Jul 1, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
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内CRISPR编辑的全基IL-13Rα2CAR T细胞用于复发的高度质瘤:临床前表征和I期试验

Xuetao Li1, Xiaoyun Shang2, Jiangang Liu3

  • 1Department of Neurosurgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.

Nature communications
|January 6, 2026
PubMed
概括

这项研究表明,全基性通用CAR-T细胞疗法 (MT026) 对复发性质母细胞瘤是安全有效的. 早期的结果表明,在治疗选择有限的患者中,瘤反应显著.

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Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

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Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor CAR T Cell Infusions in Mice05:22

Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor CAR T Cell Infusions in Mice

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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...