综合更年期的持续时间和血代谢增强了老年妇女心血管风险分层
Qi Wang1, Bo Xie1, Chunying Fu1
1Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
npj aging
|January 6, 2026
概括
绝经后的代谢变化会增加女性心血管疾病 (CVD) 的风险. 与更年期以来的时间 (TSM) 相关的新代谢特征可以帮助预测心血管疾病事件并改善风险评估.
科学领域:
- 内分泌学 在内分泌学.
- 代谢学 代谢学 代谢学
- 心血管疾病流行病学
背景情况:
- 更年期引起的代谢变化与老年女性心血管疾病 (CVD) 风险增加有关.
- 纵向代谢变化及其关于更年期 (TSM) 后时间的预测能力仍然不完全理解.
研究的目的:
- 为了确定TSM的纵向代谢相关物.
- 评估这些代谢特征对绝经后妇女心血管疾病风险的预后价值.
主要方法:
- 来自英国生物库的67,582名绝经后妇女的前性分析,没有基线心血管疾病.
- 对251种血代谢物进行核磁共振分析.
- 对心血管疾病事件的随访时间平均为13.7年.
- 弹性净回归用于识别与TSM相关的代谢学特征.
- 多变量考克斯模型和门德尔随机化分析.
主要成果:
- 与TSM相关的95个代谢物签名被确定 (斯皮尔曼r = 0.29).
- 增加的TSM (HR 1.14) 和代谢特征 (HR 1.18) 都独立地与更高的心血管疾病风险相关.
- 标志性代谢产物通过孟德尔随机化显示出在心血管疾病中的潜在因果作用.
- 将TSM或签名纳入SCORE2模型显著改善了心血管疾病风险的歧视和重新分类.
结论:
- 绝经后的累积代谢变化对血管风险有显著的贡献.
- 代谢分析提供了一个有前途的途径,以提高绝经后妇女的心血管风险分层.
- 这些发现强调了监测代谢变化对于老年妇女心血管疾病预防的重要性.
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