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Updated: Jan 13, 2026

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对于细胞内向参与研究的BRET探针的进展

Jacob L Capener1, Martin P Schwalm2, James D Vasta2

  • 1Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Nature chemical biology
|January 6, 2026
PubMed
概括

生物发光共振能量转移 (BRET) 试验提供了一个活细胞方法来测量药物与标的结合,克服了传统试验的局限性. 这项技术通过量化目标参与和探索药物机制,有助于药物发现.

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Labeling DNA Probes03:31

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
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