炎症性肠病:病理机制和治疗前景
Xiaona Yang1,2, Hong Guo3,4, Min Zou5
1Chongqing Medical University, Chongqing, 400016, China.
Molecular biomedicine
|January 6, 2026
概括
炎症性肠病 (IBD) 治疗面临着由于不反应和副作用的挑战. 新兴的战略重点是精准医学和新疗法,以改善患者的治疗结果.
科学领域:
- 胃肠道学和免疫学
- 消化系统健康 消化系统健康
- 慢性炎症疾病 慢性炎症疾病
背景情况:
- 炎症性肠道疾病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),以慢性肠道炎症为特征,全球发病率不断上升.
- 肠胃炎症显著损害生活质量,引起公众健康的关注,并导致大量的医疗保健成本.
- 目前的治疗方法,如生物药物和小分子药物,有局限性,有30-40%的患者表现为无反应,并可能产生重大副作用.
研究的目的:
- 审查IBD的发病过程,包括免疫失调,屏障损伤,微生物群失调和ROS失衡.
- 总结一下IBD临床治疗当前的挑战.
- 探索IBD个性化精密医学的新兴治疗策略和未来方向.
主要方法:
- 关于IBD病变发生的综合文献综述.
- 分析现有的IBD治疗方案的局限性.
- 整合新兴的治疗策略,包括ROS调节器,免疫调节,屏障修复,微生物群干预,多组学和人工智能辅助治疗.
主要成果:
- 确定了IBD的主要致病机制:免疫失调,肠道屏障损伤,肠道微生物群失调和ROS失衡.
- 突出了当前IBD治疗的挑战,包括不响应率和不良影响.
- 介绍了新的治疗途径,准备克服传统治疗的局限性.
结论:
- 从通用疗法过渡到个性化的精密医学对于有效的IBD管理至关重要.
- 新兴的战略提供了有希望的方向,以解决IBD治疗的未满足需求.
- 弥合基础研究和临床实践之间的差距对于推进IBD护理至关重要.
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