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Updated: Jan 13, 2026

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从三十年的小鼠BRCA1/2建模的洞察力

Julia-Star Darnold1,2, Jos Jonkers3,4

  • 1Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.

Nature genetics
|January 6, 2026
PubMed
概括

鼠标模型显著提高了我们对BRCA1/2基因功能在癌症发育和治疗反应中的理解. 未来的模型旨在进一步阐明BRCA1/2生物学,并改善患者的治疗结果.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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