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适应CAR的PIK3CD基编辑增强了T细胞的抗瘤功效

Philip Bucher1,2, Nadine Brückner1,3, Jule Kortendieck1,3

  • 1Cluster of Excellence iFIT (EXC2180) 'Image-guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.

Nature cancer
|January 6, 2026
PubMed
概括

基编辑通过微调酸-3-激酶三角酶 (PI3Kδ) 信号,优化了仿真抗原受体 (CAR) T 细胞. 特定突变增强了CAR T细胞的持久性和治疗癌症治疗的疗效.

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