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Updated: Jan 13, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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针对小分子的药理学目标介导药物排放 (TMDD) 的目标丰富性 - 一种蛋白质学方法

Min Xu1, Xuanzhen Yuan1, Peizhi Li1

  • 1Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S Grand Ave, Iowa City, Iowa, 52242, USA.

The AAPS journal
|January 6, 2026
PubMed
概括

目标介导药物排放 (TMDD) 导致非线性药理动力学 (PK),当药物点具有特定的能力时. 使用蛋白质组学量化目标量有助于预测TMDD,有助于药物开发.

关键词:
基于质谱 (MS) 的全球蛋白质组学.目标能力量化量化目标能力量化量化量目标介导性药物排放 (TMDD) 是指一种针对性药物排放.通过目标介导的非线性 PK.

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