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在早产婴儿的败血症相关的肠炎 (SA-NEC):风险因素和临床结果
Chinnathambi Nandakumar1, Chaitra Angadi1, Balaji Ramachandrin2
1Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605 006, India.
Indian journal of pediatrics
|January 6, 2026
概括
在早产婴儿中,败血症相关的死性肠球炎 (SA-NEC) 会导致更糟糕的结果,包括更高的急性损伤,穿孔和死亡率. 改善感染控制和预防NEC对于改善婴儿健康至关重要.
科学领域:
- 新生儿医学 新生儿医学
- 儿科胃肠病学 儿科胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 结核性肠球炎 (NEC) 是早产婴儿的关键性胃肠道紧急情况.
- 败血症经常使NEC复杂化,导致临床结果较差.
- 关于来自低收入和中等收入环境的NEC和败血症的数据有限.
研究的目的:
- 描述早产婴儿中NEC的临床谱和短期结果.
- 为了比较与败血症相关的NEC (SA-NEC) 与非败血症相关的NEC (非SA NEC).
主要方法:
- 在2022年3月至2025年2月期间接受≥2期NEC的早产婴儿的回顾性研究.
- SA-NEC定义为在疾病发作时具有培养证明的败血症的NEC.
- 在SA-NEC和非SA NEC组之间比较临床结果.
主要成果:
- 包括55名患有NEC的婴儿 (中位妊娠年龄31周1天);54.5%的婴儿有SA-NEC.
- 与非SA NEC相比,SA-NEC的急性损伤率 (OR 9.75),穿孔率 (OR 4.6) 和死亡率 (OR 8.9) 显著更高.
- SA-NEC代表了一个更严重的临床表型,结果较差.
结论:
- 与败血症相关的NEC与早产婴儿的短期结果明显恶化有关.
- 加强感染控制和全面的NEC预防策略是必不可少的.
- 改善早产婴儿与NEC的结果需要解决败血症的同时发生.
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