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Updated: Jan 13, 2026

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
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Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

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多发性骨髓瘤风险与DNA损伤反应基因有关

Michael Conry1, Irina Ostrovnaya2, Yelena Kemel1

  • 1Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Journal of hematology & oncology
|January 6, 2026
PubMed
概括

像TP53和ATM这样的DNA损伤反应基因 (DDRG) 的遗传突变增加了多发性骨髓瘤 (MM) 的风险,并可能预测生存率较差. 这一发现有助于识别高风险个体进行有针对性的查.

关键词:
癌症倾向症候群 癌症倾向症候群预防癌症 预防癌症癌症遗传学 癌症遗传学家庭性血液病恶性瘤遗传风险因素 遗传风险因素发生在生殖线上的倾向血细胞新生体 新生体.罕见的致病变体 罕见的致病变体罕见的变种 罕见的变种生存和预后生物标志物.

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