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多样性在多发性硬化症中的CLOCK和ARNTL/BMAL-1基因中的多态性:系统性审查和元分析

Mobina Oladghaffari¹, Heliya Bandehagh¹, Fatemeh Malekinejad¹

¹Student Research Committee, Tabriz University of Medical Sciences, Golgasht Street, 5166/15731, Tabriz, East Azerbaijan, Iran.

European journal of medical research

|January 6, 2026

概括

这项研究研究了昼夜节律基因ARNTL/BMAL-1和CLOCK在多发性硬化症 (MS) 发病过程中的研究. 研究结果表明,与多发性硬化症风险存在种族特异性遗传关联,但总体而言,在元分析中没有发现有意义的联系.

科学领域:

遗传学遗传学是一个
时间生物学时间生物学
神经免疫学神经免疫学

背景情况:

多发性硬化症 (MS) 的发病因子仍然不完全理解.
循环节律调节者,特别是ARNTL/BMAL-1和CLOCK基因,正在被探索它们在MS发展中的潜在作用.

研究的目的:

系统地审查和综合有关ARNTL/BMAL-1和CLOCK基因变异与多发性硬化症病原体之间的联系的证据.
调查与这些昼夜基因相关的MS的潜在种族特异性遗传风险因素.

主要方法:

按照PRISMA 2020指南,在主要数据库 (PubMed,Scopus,Embase,Web of Science) 进行了系统的文献搜索.
包括的研究重点是临床数据,将昼夜基因与MS病原体联系起来,并使用JBI工具评估偏差风险.
使用综合元分析 (CMA4) 进行了定量合成.

主要成果:

包括四项研究,共有4010名参与者 (2110例多发性硬化病例,1900例对照).
观察到特定种族的关联:CT基因型在CLOCK rs6811520中与伊朗人的MS风险相关;CC基因型在ARNTL/BMAL-1 rs3789327中和CLOCK rs6811520在斯拉夫人中.
在ARNTL/BMAL-1和CLOCK基因的MS病原和研究基因型之间没有发现有意义的整体统计关系 (p > 0.05).

结论:

有限的证据表明,ARNTL/BMAL-1和CLOCK基因与MS易感性之间存在潜在的种族特异关联.
由于研究数量和样本大小小小,需要进一步的多民族研究来证实这些发现.

关键词:

在 ARNTL/BMAL-1 中.钟表的时间循环节律是循环节律的节奏.进行元分析分析.多发性硬化症是多发性硬化症.系统性审查系统性审查

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