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Updated: Jan 13, 2026

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging

Published on: April 28, 2021

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通过将RPA与Rad51交换,PCNA围绕着原料/模板连接处被消除:这对人类DNA损伤耐受路径之间的相互作用有影响

Jessica L Norris1, Lindsey O Rogers1, Grace Young1

  • 1Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, United States.

Nucleic acids research
|January 7, 2026
PubMed
概括

DNA损伤耐受性 (DDT) 途径对于修复DNA复制摊位至关重要. 我们的研究表明,同源性依赖重组 (HDR) 路径激活不可逆转地卸载PCNA,影响转化合成 (TLS) 和模板切换 (TS).

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