由核心和辅助染色体编码的H3K27特异性甲基转移酶介导的选择性异色素控制真菌植物病原体中的毒性
Slavica Janevska1,2, Lucía Gómez-Gil3, Tongta Sae-Ong4
1(Epi-)Genetic Regulation of Fungal Virulence, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (Leibniz-HKI), Jena 07745, Germany.
Nucleic acids research
|January 7, 2026
概括
像H3K27me和H3K36me这样的基因组修饰,由基因组甲基转移酶调节,对于真菌病原体毒性至关重要. 在Fusarium oxysporum中,辅助染色体携带影响表观遗传特征和植物感染的基因.
科学领域:
- 植物病理学 植物病理学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 菌类遗传学 菌类遗传学
背景情况:
- 真菌植物病原体感染依赖于附属基因组区域,具有可选的异染色素.
- 这种染色质状态在毒性中的确切作用尚不清楚.
研究的目的:
- 研究H3K27me和H3K36me标记在Fusarium oxysporum毒性中的作用.
- 分析基因组甲基转移酶Kmt6和Ash1在表观遗传调节和致病性中的功能.
主要方法:
- 在Fusarium oxysporum Fol 4287.7中对基因组甲基转移酶 (KMT6A,KMT6B/C,ASH1) 的遗传分析.
- 评估H3K27me和H3K36me水平以及效应基因表达.
- 在番茄植物和Galleria mellonella中评估病原性.
主要成果:
- 辅助染色体编码的KMT6B可以补偿H3K27me中的核心KMT6A.
- 删除KMT6A或ASH1会导致效应基因的减压.
- 删除KMT6A突变显示根感染受损和番茄病原性丧失,但保留了Galleria mellonella的毒性.
结论:
- 辅助的真菌组织蛋白修饰剂有助于表观遗传特征.
- 选择性异色素素对于番茄中的Fusarium oxysporum病原性至关重要.
- 为了完全感染植物,需要通过异性染色素调节的额外毒性因子.
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