Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

DNA Bacteriophages01:26

DNA Bacteriophages

790
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
790
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

77.4K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
77.4K
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

668
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
668
Prokaryotic Gene Structure and Organization01:28

Prokaryotic Gene Structure and Organization

1.8K
Prokaryotic genomes exhibit a streamlined organization of coding and non-coding regions essential for gene expression and protein synthesis. While coding regions contain the genetic instructions for proteins or functional RNAs, non-coding regions regulate the precise transcription and translation of these genes.Coding Regions: Proteins and RNAsThe primary coding regions, known as structural genes, include sequences transcribed into messenger RNA (mRNA) and ultimately translated into...
1.8K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

20.5K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
20.5K
Bacterial Phylum Tenericutes01:24

Bacterial Phylum Tenericutes

441
The phylum Tenericutes, which includes the single class Mollicutes, comprises bacteria that lack cell walls. The term "Mollicutes" derives from the Latin word mollis, meaning "soft." These organisms are among the smallest known and are commonly referred to as mycoplasmas due to the prominence of the genus Mycoplasma, which includes well-known human pathogens. Despite their inability to stain gram-positively (a result of their lack of cell walls), mycoplasmas are phylogenetically related to the...
441

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Decoding Viral Dark Matter: Metagenomic Prokaryotic Virus Characterization With Pharokka, Phold, and Phynteny.

Current protocols·2026
Same author

Reciprocal adaptation is critical in enhancing S. aureus and P. aeruginosa biofilm biomass.

Archives of microbiology·2026
Same author

Computational prediction resolves thousands of homooligomeric phage protein structures.

bioRxiv : the preprint server for biology·2026
Same author

Structural motif search across the protein universe with Folddisco.

Nature biotechnology·2026
Same author

Reply to Stratified Anti-Biofilm Therapy: Translating Staphylococcal Exoprotein Toxicity Hierarchies Into Clinical Practice.

International forum of allergy & rhinology·2026
Same author

Gallium Protoporphyrin and Lipid Crystalline Nanoparticles Promote the Activity of Ampicillin against MRSA.

ACS infectious diseases·2026

相关实验视频

Updated: Jan 13, 2026

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

12.7K

蛋白质结构信息的细菌体基因组注释与Fold.

George Bouras1,2, Susanna R Grigson3, Milot Mirdita4

  • 1Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, 5005, Australia.

Nucleic acids research
|January 7, 2026
PubMed
概括

使用蛋白质结构的新工具Fold增强了细菌体 (菌体) 基因组注释. 与基于序列的方法相比,它提高了功能预测的准确性和速度,有助于菌体治疗的发展.

更多相关视频

An Assay for Quantifying Protein-RNA Binding in Bacteria
07:02

An Assay for Quantifying Protein-RNA Binding in Bacteria

Published on: June 12, 2019

6.9K
Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
08:31

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

11.5K

相关实验视频

Last Updated: Jan 13, 2026

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

12.7K
An Assay for Quantifying Protein-RNA Binding in Bacteria
07:02

An Assay for Quantifying Protein-RNA Binding in Bacteria

Published on: June 12, 2019

6.9K
Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
08:31

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

11.5K

科学领域:

  • * 生物信息学是一门学科.
  • * 结构生物学 * 结构生物学
  • * 病毒学 病毒学

背景情况:

  • * 细菌体 (菌体) 基因组注释对于理解病毒功能和治疗潜力至关重要.
  • *目前的方法依赖于序列同质性,这可能会限制精度和灵敏度.

研究的目的:

  • * 介绍Fold,一种利用蛋白质结构信息的新注释框架.
  • * 提高菌体基因组功能注释的准确性,速度和可扩展性.

主要方法:

  • * 折叠集成ProstT5蛋白语言模型和Foldseek结构对齐工具.
  • *使用超过136万个预测的菌体蛋白质结构与功能标签的数据库.
  • *与现有的基于序列的同类方法进行基准测试.

主要成果:

  • *与基于序列的方法相比,Fold显示出更高的功能注释灵敏度.
  • * 平均菌体基因组中超过50%的基因和古代病毒基因组中40%的基因得到了一致的注释.
  • *菌体蛋白经常表现出与生命树上保存的蛋白质的结构同质性,特别是那些参与核酸代谢和酶功能的人.

结论:

  • *Fold为菌体基因组注释提供了强大而高效的解决方案.
  • *其基于结构的方法增强了功能预测,并扩大了对菌体生物学的理解.
  • * 该工具支持基于菌体的治疗和研究的进步.