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Updated: Jun 15, 2026

DNAzyme-dependent Analysis of rRNA 2’-O-Methylation
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一种经过修改的X10-23DNA酶,可以更好地访问大型,结构化的RNA目标

Connor Nurmi1,2, Halle M Barber3, Harneesh Kaur3

  • 1Department of Biochemistry and Biomedical Sciences, McMaster University, Ontario L8S 4L8, Canada.

Nucleic acids research
|January 7, 2026
PubMed
概括

一种新型的10-23 DNA酶,XdZ-2,利用修饰核酸 (XNA) 来有效地切割大型结构化RNA (lsRNA) 标,如SARS-CoV-2的标,提供更好的活性和稳定性.

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Ribozymes

The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
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Ribozymes02:47

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The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
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