用皮达或尼托福兰治疗的无并发性尿路感染患者的早期症状反应:来自两个关键的第三期研究的综合分析
Amanda J Sheets1, Jeremy Dennison2, Jason M Pogue3
1GSK, Collegeville, PA, USA.
概括
盖波蒂素和尼特鲁福兰可以提供相似的,显著的缓解无并发性尿路感染 (UTI) 症状. 这两种治疗都有效地减少了症状严重程度,并在治疗早期改善了日常功能.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 无并发性尿路感染 (UTI) 引起患者严重的痛苦,并影响日常活动.
- 早期缓解症状对患者至关重要,但在临床试验中通常代表性不足.
- 在先前的试验中,盖波蒂达在治疗UTI方面表现出与尼托福兰因的非劣势.
研究的目的:
- 为了评估和比较UTI治疗期间和之后的症状反应.
- 分析来自EAGLE-2和EAGLE-3随机对照试验的数据.
- 为了评估gepotidacin与nitrofurantoin对患者报告的症状的影响.
主要方法:
- 在两个随机对照试验 (EAGLE-2和EAGLE-3) 中,共有3136名参与者的数据.
- 年龄≥12岁,患有尿路感染症状的参与者随机获得口服葛波蒂或尼特洛黄5天.
- 在基线,治疗期间 (2-4日) 和治愈测试 (10-13日) 评估的尿路症状得分.
主要成果:
- 吉波蒂素和尼托福兰因双臂均显示,平均症状得分从基线下降 (大约为1. 7.1) 在治疗期间 (大约. 3.6) 的情况.
- >80%的参与者在治疗访问时经历了临床改善/解决.
- 在治疗期间访问时,超过53%的中度/严重基线症状的参与者报告说对日常活动没有影响,在治愈测试时增加到93%以上.
结论:
- 盖波蒂达和尼托福兰在不复杂的尿路感染中提供了类似和有意义的早期症状缓解.
- 这两种疗法都有效地缓解了尿路感染症状,改善了患者的日常功能.
- 这些发现支持这两种药物在治疗UTI症状方面的有用性.
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