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Reticular Dermis

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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相关实验视频

Updated: May 10, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

一个基于人类的皮肤淋巴管模型芯片,以模拟炎症性皮肤疾病.

Zheng Tan¹, Partho Protim Adhikary¹, Dana Wörz²

¹Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.

Advanced healthcare materials

|January 7, 2026

概括

研究人员开发了一个基于人类的皮肤淋巴管模型来研究免疫反应. 这种生物工程系统模仿了皮肤和排水淋巴结之间的相互作用,有助于理解炎症状况.

关键词:

亚托皮性疾病 (Atopic Diseases) 是一种亚托皮性疾病.生物工程的淋巴结生物工程的淋巴结基于人类的模型.淋巴细胞组织模型器官在芯片上的器官二次性淋巴状组织组织.皮肤敏感化皮肤敏感化

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Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

相关实验视频

Last Updated: May 10, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

科学领域:

生物工程是生物工程.
免疫学免疫学免疫学
组织工程是组织工程.

背景情况:

基于人类的生物工程模型努力复制复杂的免疫调节.
现有的模型往往缺乏对免疫反应至关重要的二次淋巴组织.

研究的目的:

创建一个自组装,功能性淋巴管单元,模拟人体淋巴组织.
为研究炎症下皮肤-淋巴结相互作用建立共同培养系统.

主要方法:

纤维细胞网状细胞,淋巴内皮细胞和CD4+ T细胞的层层组合.
开发一个微流体器官在芯片上的平台,用于皮肤-淋巴细胞共培.
验证T细胞迁移和对炎症刺激和抗炎药物的反应.

主要成果:

成功创建了一个自我组织的,分隔的淋巴细胞模型.
该模型表明,T细胞迁移和透是对亚托皮类皮肤模型和敏感剂的反应.
抗炎药物有效地废除了T细胞介导作用,证实了模型的功能.

结论:

开发的基于人类的皮肤淋巴管模型代表了研究皮肤淋巴管相互作用的最小功能单元.
这个模型为研究人类相关环境中的免疫反应提供了一个新的平台.
该系统允许评估针对皮肤相关炎症的治疗干预措施.