基于诺普拉桑的斯木斯四重疗法用于一线的Helicobacter pylori根除:一个现实世界的回顾性研究
Jin-Yan Zhang1,2, Yan-Qing Wang3, Wei-Feng Huang1
1Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Medicine
|January 7, 2026
概括
基于诺普拉桑 (VPZ) 的双四重疗法 (BQT) 提供了一种高效的第一线治疗,用于根除Helicobacter pylori. 这种疗法在中国人群中显示出出色的安全性和患者遵守性.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 耐药Helicobacter pylori菌株的流行率不断增加,需要新的根除策略.
- 双四次疗法 (BQT) 是一种有前途的方法,用于根除H. pylori.
- 诺普拉桑 (VPZ) 是一种与具有竞争力的酸阻断剂,有可能提高根除效率.
研究的目的:
- 评估基于诺普拉桑 (VPZ) 的BQT作为一线H. pylori根除方案的疗效和安全性.
- 评估患者遵守和与基于VPZ的BQT相关的不良事件.
- 确定影响H. pylori根除治疗成功的因素.
主要方法:
- 对231名先前未接受过治疗的H. pylori患者进行了回顾性分析,这些患者接受了14天的基于VPZ的BQT.
- 治疗方案包括VPZ (20毫克),酸,氨基和清素,每天服用两次.
- 评估了根除率,合规性和不良事件 (AE).
主要成果:
- 实现了高的根除率:92.2% (治疗意图),97.3% (修改治疗意图) 和99.1% (每个协议).
- 报告的患者遵守率为97.0%,非常出色.
- 在22.1%的患者中发生了不良事件,大多是轻微的和可以容忍的.
结论:
- 基于VPZ的14天BQT是中国环境中高效和安全的第一线H. pylori根除方案.
- 优秀的患者遵从性有助于治疗成功.
- 不良的遵守是H. pylori根除失败的独立预测因素.
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