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红细胞分布宽度与白蛋白比率与慢性病之间的关联:一个横截面研究
Jie Li1, Yabin Wang, Xinyi Hao
1Nephrology Department, The First Affiliated Hospital of Qingdao University, Qingdao, China.
Medicine
|January 7, 2026
概括
较高的红细胞分布宽度与白蛋白比率 (RAR) 与美国成年人慢性病 (CKD) 患病率的增加有关. 这种易于获取的生物标志物可能有助于早期评估CKD风险和个性化管理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 生物标志物 生物标志物
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 是一个重要的公共卫生问题,早期检测方法有限.
- 红细胞分布宽度与白蛋白比率 (RAR) 是一个反映炎症和营养状况的新兴生物标志物.
- 在美国一般成年人群中,RAR和CKD患病率之间存在关联的证据很少.
研究的目的:
- 研究红细胞分布宽度与白蛋白比率 (RAR) 与慢性病 (CKD) 患病率之间的关联.
- 评估RAR对CKD的预测能力,在一个庞大的,全国代表性的美国成年人群中.
主要方法:
- 采用2005-2018年国家健康和营养检查调查 (NHANES) 数据进行的横截面研究.
- 根据人口统计学,生活方式,代谢因素和并发症进行调整的加权多变量后勤回归模型.
- 使用了受限立方线,子组和接收器操作特征 (ROC) 曲线分析.
主要成果:
- 在完全调整后,在较高的RAR和增加的CKD患病率之间发现了显著的积极关联.
- 证实了RAR和CKD患病率之间的正非线性关系.
- RAR显示了对CKD的一定的预测能力,在各种子组之间有着一致的积极关联.
结论:
- 升高的RAR显著与美国成年人中CKD的更高患病率有关.
- 作为综合炎症和营养状况的可访问生物标志物,RAR显示了早期CKD风险评估的潜力.
- RAR可能有助于开发针对CKD的个性化管理策略.
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