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通过氧化应激和破坏线粒体可塑性诱导的多器官毒性,由斑马鱼中的 bendiocarb 诱导
Kyu Seomoon1, Hojun Lee2, Taeyeon Hong1
1Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Redox biology
|January 7, 2026
概括
昆虫杀虫剂bendiocarb通过损害器官和破坏能量生产来损害斑马鱼的发育. N-乙半氨酸 (NAC) 治疗显著降低了这些毒性影响,突出了潜在的治疗策略.
科学领域:
- 毒理学 毒理学 毒理学
- 发展生物学 发展生物学
- 环境科学 环境科学
背景情况:
- 碳酸盐杀虫剂本迪奥卡布 (Bendiocarb) 广泛使用,但对非标生物体构成风险.
- 尚不清楚bendiocarb对早期和器官发育的影响.
研究的目的:
- 研究斑马鱼中本迪奥卡布的发育和器官特异性毒性机制.
- 探索N-乙半氨酸 (NAC) 对抗 bendiocarb 诱导的毒性的保护作用.
主要方法:
- 使用斑马鱼模型 (转基因线) 来评估多器官毒性 (心脏,血管,肝脏,胰腺,神经元).
- 分析了分子变化,使用整个山在现场杂交和qPCR.
- 评估了活性氧物种的产生,抗氧化基因表达和线粒体生物能量学.
主要成果:
- 暴露于本迪奥卡布减少了斑马鱼幼虫的生存能力,诱导了氧化应激,并降低了抗氧化基因表达 (cat, sod2).
- 观察到线粒体功能受损 (减少ATP生成) 和多器官毒性 (心脏,血管,肝脏,胰腺,神经系统).
- 与N-乙半氨酸 (NAC) 联合治疗改善了多个器官系统中 bendiocarb 诱导的发育毒性.
结论:
- 班迪奥卡布通过影响器官发育和功能的分子机制产生系统级毒性.
- 斑马鱼作为一种有价值的模型,用于了解杀虫剂的发育毒性.
- NAC显示出作为治疗剂的潜力,可以对抗 bendiocarb 诱导的发育损害.
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