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Updated: Jan 13, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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基于生理学的动力学建模用于物种抽取小型哺乳动物之间的毒性动力学数据:系统评估

L Villain1, S Schaller1, D Lefaudeux1

  • 1ESQlabs GmbH, Am Sportplatz 7, Saterland 26683, Germany.

Environment international
|January 7, 2026
PubMed
概括

基于生理学的动力学 (PBK) 模型改善了用于环境风险评估的跨物种推断. 有限的体外试验数据可以实现强大的推断,接近生态毒理学直接适合的准确性.

关键词:
动物替代品 动物替代品在PBPK建模中使用PBPK模型.药品制造业 药品制造业 药品制造业 药品制造业动物 动物小型哺乳动物 小型哺乳动物

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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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