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在中风患者中模拟tDCS诱导的电场:需要现实的损伤头部模型

Ikko Kimura¹, Marcus Meinzer², Daria Antonenko²

¹Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark.

NeuroImage. Clinical

|January 7, 2026

概括

脑卒中病变显著影响跨直流刺激 (tDCS) 电场,影响脑卒中后失言症康复. 逼真的病变建模对于准确的tDCS模拟和个性化治疗至关重要.

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
康复医学康复医学康复医学

背景情况:

跨直流刺激 (tDCS) 在中风后失语康复方面表现有前途.
个性化的tDCS模拟需要精确的电场 (E-fields) 建模.
脑卒中病变的复杂性挑战了tDCS模拟的准确性.

研究的目的:

评估中风病变对tDCS诱导的E场的影响.
调查病变大小,形状和导电性对E场精度的影响.
评估在tDCS模拟中实现真实的病变建模的必要性.

主要方法:

分析了中风患者和健康对照组的结构和扩散MRI数据.
在健康模型中模拟E场的比较,有和没有人造损伤.
使用均质与现实的损伤导电性模型评估E场差异.

主要成果:

人工损伤在感兴趣的区域改变了E场强度高达47%.
在患者内部和患者之间观察到损伤导电性的显著变化.
与同质模型相比,现实的损伤模型产生了小到中等的E场差异.

结论:

脑卒中病变在tDCS诱导的E场中带来了相当大的变化.
准确的tDCS模拟需要具有真实的损伤表示 (形状,大小,导电性) 的头部模型.
改进的模拟精度可以指导个性化的tDCS协议用于中风康复.

关键词:

亚法西亚 (Aphasia) 是一种语言障碍.扩散到导电性的映射绘制.神经康复疗法神经康复疗法这就是SIMNIBS.通过皮电刺激.扩散磁力共振成像 (MRI) 扩散

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