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围产期窒息对两岁儿童皮质活动的影响
Sebastian König1, Anna Tuiskula2, Marjo Metsäranta2
1Early Brain Activity, Systems and Health Group, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland; Department of Physiology, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland; Department of Neuroscience and Bioengineering, Aalto University, Rakentajanaukio 2, 02150 Espoo, Finland.
NeuroImage. Clinical
|January 7, 2026
概括
围产期窒息 (PA),即使没有缺氧缺血性脑病变 (HIE),也可能导致大脑活动网络的持久变化. 这些皮质功能变化可能会影响儿童的大脑发育.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 儿科 儿科 儿科
背景情况:
- 围产期窒息 (PA) 是新生儿脑损伤的一个重要危险因素.
- 低毒性缺血性脑病变 (HIE) 是PA的严重后果,与高发病率和死亡率有关.
- 没有临床HIE的PA对大脑网络的长期影响尚不清楚.
研究的目的:
- 调查PA与HIE和没有HIE对皮质活动网络的长期影响.
- 为了比较只有PA的儿童的大脑功能,PA与HIE,以及两岁的健康对照.
主要方法:
- 电脑电图 (EEG) 记录在睡眠期间从三个组中获得:只有PA (n=10),PA有轻度至中度HIE (n=8),健康对照 (n=37).
- 分析的重点是局部皮层功能和皮层-皮层网络的群体差异,包括频率特定的幅度和相相关网络.
主要成果:
- 与对照组相比,PA和HIE组显示频率特异幅度减少.
- 患有PA的儿童表现出变化的振幅相关网络 (在低频段更强,在高频段更弱).
- 患有HIE的儿童表现出所有频率的连接性下降.
- 在PA组中,相相关网络也发生了变化 (在低频段更强,在高频段更弱).
结论:
- 围产期窒息,即使没有临床HIE,也与皮质活动和大规模大脑网络的持续变化有关.
- 这些神经生理学变化可能会对正常的大脑功能和发育产生影响.
- 需要进一步的研究,以充分阐明PA对长期神经结果的影响.
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