胎儿的功能连接性可能与幼儿时期的自闭症特征有关
Bosi Chen1, Iris Menu2, Lanxin Ji1
1Department of Child and Adolescent Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.
NeuroImage. Clinical
|January 7, 2026
概括
这项研究发现,胎儿的功能性大脑连接可以预测幼儿的自闭症特征. 胎儿大脑网络的差异与晚期自闭症谱系障碍 (ASD) 的可能性有关.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 自闭症谱系障碍 (ASD) 研究研究
背景情况:
- 自闭症谱系障碍 (ASD) 与大脑连接的改变有关,即使在婴儿期也可以观察到.
- 以前的研究还没有探讨胎儿的产前功能连接差异,这些胎儿后来发展出自闭症特征.
研究的目的:
- 为了调查功能性大脑连接的差异是否存在于胎儿阶段的个体,后来表现出自闭症特征.
- 为了确定与后来的自闭症特征相关的特定产前神经网络模式.
主要方法:
- 利用了62名儿童的纵向数据,其中包括胎儿大脑静止状态MRI扫描和3岁时父母报告的自闭症特征.
- 采用丰富和特异性分析,将胎儿的功能连接与自闭症特征相关联,控制其他儿童精神病理.
主要成果:
- 发现自闭症特征和功能连接性之间的显著正相关性,在带膜-左和右前额叶-左骨网络对.
- 视觉网络连接与前额叶和部区域显示与自闭症特征的关联.
- 在特异性分析中,较弱的小脑-右骨连接性与更高的自闭症特征有独特的关联.
结论:
- 这项研究提供了第一个体内,前性证据,将胎儿大脑功能网络连接与幼儿时期的自闭症特征联系起来.
- 研究结果表明,与自闭症相关的神经差异的潜在产前起源.
- 胎儿静止状态MRI (rs-fMRI) 可以作为一种工具来识别与社会情绪发展和ASD风险相关的早期神经特征.
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