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综合空间和单细胞转录组学揭示了RPL8作为肝细胞癌的预后生物标志物和治疗标

Jinna Tan¹, Junzhu Liang², Yaoyang Li²

¹Guangxi University of Chinese Medicine, Nanning 530200, China; First Clinical Medical College, Guangxi University of Chinese Medicine, Nanning, 530022, China.

Translational oncology

|January 7, 2026

概括

核糖体蛋白L8 (RPL8) 驱动肝细胞癌 (HCC) 的进展和免疫逃避. 这种蛋白质是一个有前途的诊断生物标志物和HCC的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

核糖体蛋白L8 (RPL8) 在肝细胞癌 (HCC) 中被上调.
目前尚不清楚RPL8在HCC中的临床意义和微环境作用.

研究的目的:

研究RPL8在HCC中的临床价值和微环境作用.
探索RPL8作为潜在的诊断生物标志物和HCC的治疗点.

主要方法:

集成的多omics数据 (TCGA,CPTAC) 和单细胞/空间转录组 (GSE146115).
进行了RPL8敲击,扩散/迁移测定和药物敏感性选.
分析了RPL8表达,生存预测,信号通路和免疫细胞透.

主要成果:

在HCC中,RPL8mRNA/蛋白质水平显著升高,显示出高诊断准确度 (AUC0.95).
高RPL8独立预测较短的整体和疾病特异性生存时间.
通过激活MYC/G2M信号,改变谷氨代谢,并促进免疫逃避,RPL8促进了HCC的进展.
沉默RPL8降低了增殖,迁移,谷氨合成,并使HCC细胞对特定药物敏感.

结论:

RPL8在推动HCC进展和免疫逃避方面发挥着至关重要的作用.
RPL8作为HCC的有价值的诊断生物标志物.
RPL8代表了HCC治疗的潜在治疗标.

关键词:

生物标志物生物标志物肝细胞癌是肝细胞癌.综合的多主题分析.RPL8 RPL8 是一个专业的专业.单细胞测序是一个单细胞的测序.空间转录组学空间转录组学

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