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儿科发病的毛囊炎Decalvans和Lichen Planopilaris表型谱:这是一个不同的疾病吗?
Andrew Awad1, Yong Chern Kho2, Leila Asfour3
1Department of Dermatology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Experimental dermatology
|January 7, 2026
概括
毛囊炎 (Folliculitis decalvans and lichen planopilaris) 现象谱 (FDLPPPS) 是一种侵袭性痕性脱毛症,可以在儿童时期表现出来. 这种常常与皮性角质炎相关的疾病,具有独特的临床和本病理学特征.
科学领域:
- 皮肤病学 皮肤病学
- 病理学 病理学 病理学
背景情况:
- 毛囊炎 (FD) 和 (LPP) 是不同的原发性痕性脱发 (PCA).
- 毛囊炎的表型谱 (FDLPPPS) 描述了具有FD和LPP重叠特征的病例.
- FDLPPPS是一种罕见的疾病,对儿科发病的数据有限.
研究的目的:
- 描述FDLPPPS在儿童时期出现的临床病理特征.
- 为了评估儿科FDLPPPS病例的治疗反应.
- 探索潜在的关联,如皮质疏松症.
主要方法:
- 从四个国际皮肤病诊所对儿科FDLPPPS病例 (发病年龄≤18岁) 的回顾性审查.
- 数据收集包括临床表现,三镜,组织病理学和治疗结果.
- 对2020年8月至2024年2月期间诊断的14名儿科患者的分析.
主要成果:
- 确定了14名患者 (10名女性,4名男性),平均发病年龄为12.4岁.
- 常见的症状包括,疼痛,,红和.
- 组织病理学显示,在大多数情况下,周围毛囊性淋巴细胞透和集中层状纤维化. 八名患者患有皮质疏松症或其变体.
- 在7名患者中实现了疾病稳定,但6名患者继续出现脱发.
结论:
- 在儿童时期,FDLPPPS会呈现出激烈的表现,这会给诊断带来挑战.
- 与皮质疏松症 (keratosis pilaris) 的关联表明,与皮质疏松症疾病的潜在联系.
- 需要进一步的研究,以了解病变发生和优化儿科FDLPPPS的治疗.
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