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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
通过Dearomative循环-核性捕获序列通过螺旋环氧醇和二二二的形成
Bing-Xia Wang1, Bin-Xiang Yang1, Bao-Yu Du1
1College of Chemical Engineering, State Key Laboratory of Advanced Separation Membrane Materials, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014, China.
这项研究引入了一种新的催化方法,用于印和酸的芳香性功能丧失. 该过程通过螺旋循环和核性添加有效合成螺旋氧indoles和螺旋二二enzofurans.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 异环化学 异环化学
背景情况:
- Dearomative 不功能化为复杂的异质环化合物提供了直接的途径.
- 的催化是C-H功能化和C-C键形成的强大工具.
研究的目的:
- 开发一种新型的催化剂,用于印和酸的芳香性功能丧失.
- 通过螺旋循环和核性添加合成螺旋氧indoles和螺旋二二enzofurans.
主要方法:
- 催化C3-基因结合的基化.
- Dearomative 螺旋循环化,其次是用甲醇添加核性添加.
- 用乙酸对C3-基因结合的福兰进行脱氧化.
主要成果:
- 一系列的螺旋氧indoles 在中等到良好的产量合成.
- 螺旋二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二三二二二
- 进行了关于不对称合成和产品转换的初步研究.
结论:
- 开发的方法为构建螺旋环异环化合物提供了一条有效的途径.
- 这项工作扩大了有机合成中 dearomative difunctionalization 策略的范围.
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