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Updated: Jan 13, 2026

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
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Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

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一个模块化和融合的"粘贴和点击"结合平台使得快速的抗体结合图书馆合成.

Connor Livingstone1,2, Simon Nicolle1, Gavin Jones1

  • 1GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, U.K., SG1 2NY.

Bioconjugate chemistry
|January 7, 2026
PubMed
概括

我们开发了一个模块化平台,以高效地创建抗体药物联合体 (ADC). 这种方法可以快速定制有效载荷,链接器和结合方法,简化ADC开发.

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相关概念视频

Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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