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Updated: Jan 13, 2026

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AKG-TET轴是衰老可塑性的核心

Shin Akakura1, Siamak Tabibzadeh1

  • 1Frontiers in Bioscience Research Institute in Aging and Cancer, 16471 Scientific Way, Irvine, CA 92618, USA.

iScience
|January 7, 2026
PubMed
概括

与衰老相关的细胞衰老是由α-甲酸盐 (AKG) -十-十一转位 (TET) 轴调节的. 操纵这个轴会影响表观遗传重编程,炎症和与衰老相关的分泌表型 (SASP).

关键词:
生物化学 生物化学细胞生物学 细胞生物学

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