在接受放射治疗的头癌患者口腔粘膜炎的屏障形成凝:随机,受控,多中心试验
Jinlong Wei1,2,3, Qin Zhao1,2,3, Sitong Chang1,2,3
1Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, 130021, China.
在接受放射治疗的头癌 (HNC) 患者中,Episil凝减少了严重的口腔粘膜炎 (OM) 和疼痛. 这种形成屏障的凝还改善了营养状况和生活质量 (QOL).
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 胃肠病学 胃肠病学
背景情况:
- 接受放射治疗的头癌 (HNC) 患者经常患上口腔粘膜炎 (OM),这是一种痛苦的疾病,影响营养状况和生活质量 (QOL).
- 研究人员研究了一种形成屏障的凝Episil,研究其减轻这些不良影响的潜力.
研究的目的:
- 评估Episil在降低接受放射治疗的HNC患者OM发生率和严重性的疗效.
- 评估Episil对这种患者群体的疼痛缓解,营养状况和QOL的影响.
主要方法:
- 进行了一项多中心,随机对照试验,涉及200名HNC患者.
- 患者被分配到对照组 (口腔嘴液) 或Episil组 (嘴干预后Episil喷雾).
- 主要终点是晚期OM的发病率;次要终点包括疼痛,营养状况,存活率,免疫功能,QOL和不良反应.
主要成果:
- 在Episil组中,III/IV级OM的发病率明显低于Episil组 (4%) 与对照组 (14%) 相比 (P=0.024).
- 在治疗后2小时和4小时,Episil显著改善了口腔疼痛缓解 (P<0.0001).
- 在Episil组的患者在4周后体重减轻,BMI下降和前专辑蛋白损失较少 (分别P=0.036,P=0.040,P=0.0040),并且报告了更好的QOL得分 (P<0.0001).
结论:
- 在接受放射治疗的HNC患者中,Episil在延迟先进的OM和缓解口腔疼痛方面显示出显著的潜力.
- 使用Episil也有助于改善营养状况和生活质量.
- 需要进一步的大规模,跨国前性研究来证实这些发现.
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