肠道微生物群门宿主暴露于饮食中的Solanums的胆酶抑制剂
Catherine S Liou1, Tijs Louwies2, Mikhail Iakiviak3
1Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
bioRxiv : the preprint server for biology
|January 7, 2026
概括
食夜色含有类固醇类化合物,这些类化合物被肠道微生物广泛修饰. 这种微生物代谢影响宿主生理学,并且在个体之间有很大的差异.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 饮食生物化学 饮食生物化学
背景情况:
- 食植物含有许多化合物,其摄入后的命运和健康影响尚不清楚.
- 索拉努姆 (Solanum) 种类 (夜色) 被广泛消费,但它们对人类新陈代谢的化学贡献尚不清楚.
研究的目的:
- 描述Solanum物种对人类新陈代谢的化学贡献.
- 调查肠道微生物群在修改这些食化合物的作用.
- 了解这些饮食与微生物相互作用的生理影响.
主要方法:
- 使用非向代谢学来识别摄入番茄和土豆后在全身循环中的化合物.
- 殖民和微生物群枯竭的小鼠模型被用来评估化合物的微生物修饰.
- 人类尿液和便样本进行了查,并分析了微生物菌株的代谢活性.
主要成果:
- 类固醇类化合物 (来自糖类类化合物 tomatine,solanine,chaconine) 是主要的饮食衍生化合物.
- 肠道微生物群广泛修改这些化合物,影响宿主吸收和暴露.
- 代谢在个体之间有所不同,由特定的微生物菌株和社区组成驱动.
- 微生物的新陈代谢改变了乙胆酶抑制和肠道运动.
结论:
- 肠道微生物群在加工饮食中的Solanum代谢物中起着至关重要的作用.
- 个体肠道微生物组的组成决定了宿主暴露和生理反应.
- 这项研究阐明了饮食与微生物群相互作用的分子机制及其对健康的影响.
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