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Updated: Jan 13, 2026

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同等的CD47免疫毒素用于肺癌向治疗

Jihong Ma, Dinoop Ravindran Menon, Zhaohui Wang

bioRxiv : the preprint server for biology

|January 7, 2026

概括

一种基于白喉毒素的新型免疫毒素向CD47受体,显示出治疗非小细胞肺癌 (NSCLC) 的前景. 这种治疗方法,双CD47-IT,在各种肺癌模型中显示出显著的临床前疗效.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
分子生物学分子生物学

背景情况:

肺癌仍然是全球癌症死亡的主要原因,需要改善治疗方法.
虽然有针对性和免疫疗法已经推进了肺癌治疗,但对于晚期和耐药病例来说,持久的反应仍然是一个挑战.
肺癌细胞上的CD47受体过度表达是一个治疗标,但CD47向抗体在临床试验中面临毒性问题.

研究的目的:

开发一种基于白喉毒素的新型双价CD47免疫毒素 (双CD47-IT) 用于针对性治疗CD47阳性非小细胞肺癌 (NSCLC).
在各种NSCLC小鼠模型中评估双CD47-IT的临床前疗效和安全性.

主要方法:

利用一种独特的抗白喉毒素的Pichia pastoris酵母表达系统来创建双CD47-IT.
在多个NSCLC细胞系衍生异种移植 (CDX) 和患者衍生异种移植 (PDX) 鼠标模型中测试了双CD47-IT,包括皮下,正位,转移和人性化模型.

主要成果:

双CD47-IT在各种NSCLC模型中显示出令人信服的临床前疗效.
免疫毒素在代表不同阶段和类型肺癌进展的模型中显示出显著的抗瘤活性.

结论:

双CD47-IT代表了针对非小细胞肺癌的新且有前途的治疗方法.
这种基于甲状腺毒素的免疫毒素克服了以前的CD47向策略的局限性,为NSCLC患者提供了持久反应的潜力.

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