在癌症化疗期间人类肠道微生物群的变化取决于饮食
Kai R Trepka1, Erin L Van Blarigan2,3, Than S Kyaw1
1Department of Microbiology and Immunology, University of California, San Francisco, CA, United States.
在癌症化疗期间,患者的饮食质量下降,影响肠道微生物群多样性,并可能恶化副作用. 在治疗期间的饮食变化会影响肠道细菌和药物敏感性.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 营养科学 营养科学
背景情况:
- 饮食摄入量和肠道微生物组与结直肠癌 (CRC) 治疗结果有关.
- 患者如何在化疗期间改变饮食及其对微生物群的影响仍然不清楚.
研究的目的:
- 分析CRC化疗期间的纵向饮食和微生物组变化.
- 研究饮食转变对肠道微生物群和治疗结果的影响.
主要方法:
- 在接受口服胺的CRC患者中对长度饮食和微生物组分析.
- 细胞培养试验验证了关键的饮食微生物组关联.
- 饮食成分与微生物多样性,丰富性和基因家族的相关性分析.
主要成果:
- 化疗导致饮食质量下降,碳水化合物/精制谷物摄入量增加,脂肪/微量营养素消耗量减少.
- 饮食变化与改变的肠道微生物群多样性,分类构成 (例如, *Faecalibacterium prausnitzii* 枯竭) 和细菌基因家族相关.
- 降低神胺摄入量与较低的微生物多样性和更多的毒性有关;增加的铜摄入量与减少的*Fusobacterium nucleatum*有关.
结论:
- 化疗引起的饮食变化会对肠道微生物组合和多样性产生负面影响.
- 饮食中微量营养素的摄入影响肠道细菌,可能影响药物敏感性和治疗毒性.
- 收集详细的饮食数据对于了解和管理癌症治疗对肠道微生物群的影响至关重要.
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