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皮肤活检的分子见解:解读外周血管疾病中的微血管病理

Maneesha Kumari¹, Narainder Kumar², Rahol Meghwar²

¹Department of Medicine, Peoples University of Medical and Health Sciences, Nawabshah 67480, Sindh, Pakistan.

World journal of experimental medicine

|January 7, 2026

概括

皮肤活检对于诊断外围血管疾病 (PVD),识别微血管变化和特定疾病非常有价值. 需要进一步的标准化和分子技术来提高PVD诊断的准确性.

科学领域:

血管医学血管医学
皮肤病理学皮肤病理学
诊断病理学的诊断病理学

背景情况:

周围血管疾病 (PVD) 是一组导致心脏和大脑以外缺血的疾病.
准确诊断PVD对于及时有效的患者管理至关重要.
皮肤活检为PVD相关的微血管变化提供了他的病理学和分子洞察力.

研究的目的:

评估皮肤活检在诊断外周血管疾病 (PVDs) 中的有用性.
分析PVD诊断皮肤活检中的技术方面,病理指标和新型分子标记.

主要方法:

随机对照试验和原始研究的系统审查.
在PubMed,Scopus和EMBASE数据库中进行的搜索.
纳入标准侧重于特定研究类型,不包括案例报告和综述.

主要成果:

22项研究符合评估的纳入标准.
皮肤活检有效地区分炎症性和非炎症性PVDs.
检测到系统性硬化和糖尿病血管病的微血管异常.
使用像VEGF,ICAM-1和eNOS这样的标记物确定了内皮功能障碍.
限制包括患者的不适和诊断解释的变化.

结论:

皮肤活检为PVD检测和患者管理提供了关键的诊断信息.
建议对活检程序和分子诊断技术进行标准化,以促进PVD诊断.
需要进一步的研究来完善皮肤活检方法,以改善临床应用.

关键词:

组织病理学组织病理学微血管病理学微血管病理学分子标记物分子标记物周围血管疾病周围血管疾病皮肤活检皮肤活检

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